About me

ImmuneAxisa hosts academic work from Pierre-Paul Axisa and colleagues. I work at CRCT, where I analyse transcriptomic and epigenetic assays to study in the immune system in cancer, aging, and autoimmunity.

You can check my academic work on google scholar, follow and contact me on twitter

Publications

Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis

J Wei, J Moon, L Zhang, K Radassi, N Buitrago-Pocasangre, Y Yasumizu, M Deerhake, N Strauli, A Chan, A Herman, R Pedotte, C Raposo, J Pappalardo, E Longbrake, T Sumida, PP Axisa*, DA Hafler*. * equal contribution

bioRxiv 2024

Inflamed Natural Killer cells with adhesion defects are associated with a poor prognosis in Multiple Myeloma

E Blanquart, R Ekren, B Rigaud, MV Joubert, H Daunes, M Cuisinier, M Villard, N Carrié, C Mazzotti, V Baylot, LE Lucca, A Perrot, J Corre, T Walzer, H Avet-Loiseau, PP Axisa*, L Martinet*. * equal contribution

bioRxiv 2024

The tidyomics ecosystem: Enhancing omic data analyses

WJ Hutchison, TJ Keyes, T Consortium, LH Crowell, C Soneson, V Yuan, AA Nahid, W Mu, J Park, ES Davis, M Tang, PP Axisa, JW Kitt, CL Poon, M Kosmac, J Serizay, N Sato, R Gottardo, M Morgan, S Lee, M Lawrence, SC Hicks, GP Nolan, KL Davis, AT Papenfuss, M Love, S Mangiola.

bioRxiv 2023

TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation

AC Pichler, Nèg Carrié, M Cuisinier, S Ghazali, A Voisin, PP Axisa, M Tosolini, Cél Mazzotti, DP Golec, S Maheo, LD Souto, Rüçh Ekren, E Blanquart, L Lemaitre, V Feliu, M-Vér Joubert, JL Cannons, C Guillerey, Hé Avet-Loiseau, TH Watts, BL Salomon, O Joffre, Y Grinberg-Bleyer, PL Schwarzberg, LE Lucca, L Martinet.

Immunity 2023

A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells

PP Axisa, TM Yoshida, LE Lucca, HG Kasler, MR Lincoln, GH Pham, DD Priore, J-M Carpier, CL Lucas, E Verdin, TS Sumida, DA Hafler.

Science Translational Medicine 2022

Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis

H Asashima, PP Axisa, THG Pham, EE Longbrake, WE Ruff, N Lele, I Cohen, K Raddassi, TS Sumida, DA Hafler.

The Journal of Clinical Investigation 2022

Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells

TS Sumida, S Dulberg, JC Schupp, MR Lincoln, HA Stillwell, PP Axisa, M Comi, A Unterman, N Kaminski, A Madi, VK Kuchroo, DA Hafler.

Nature Immunology 2022

Joint analysis reveals shared autoimmune disease associations and identifies common mechanisms

MR Lincoln, N Connally, PP Axisa, C Gasperi, M Mitrovic, Dv Heel, C Wijmenga, S Withoff, IH Jonkers, L Padyukov, IMSG Consortium, SS Rich, RR Graham, PM Gaffney, CD Langefeld, DA Hafler, S Chun, SR Sunayev, C Cotsapas.

medRxiv 2021

Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells

LE Lucca, PP Axisa, B Lu, B Harnett, S Jessel, L Zhang, K Raddassi, L Zhang, K Olino, J Clune, M Singer, HM Kluger, DA Hafler.

Journal of Experimental Medicine 2021

Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity

MR Lincoln, PP Axisa*, DA Hafler. * corresponding author

Current Opinion in Immunology 2020

TIGIT signaling restores suppressor function of Th1 Tregs

LE Lucca, PP Axisa, ER Singer, NM Nolan, M Dominguez-Villar, DA Hafler.

JCI insight 2019

Podoplanin is a negative regulator of Th17 inflammation

AN Nylander, GD Ponath, PP Axisa, M Mubarak, M Tomayko, VK Kuchroo, D Pitt, DA Hafler.

JCI insight 2017

Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4+ T cells specific for both a myelin and a neuronal self‐antigen in mice

LE Lucca*, PP Axisa*, M Aloulou, C Perals, A Ramadan, P Rufas, B Kyewski, J Derbinski, N Fazilleau, LT Mars, RS Liblau. * equal contribution

European journal of immunology 2016

Multiple sclerosis: genetics, biomarkers, treatments

PP Axisa, DA Hafler.

Current opinion in neurology 2016

In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS

A Ramadan, LE Lucca, Nèg Carrié, S Desbois, PP Axisa, M Hayder, J Bauer, RS Liblau, LT Mars.

Brain 2016